王庭芳，副研究员、硕士生导师，入选上海市东方英才青年项目（原上海市青年拔尖人才）。2016毕业于中国药科大学获药物化学博士学位，师从张灿教授。2016年入职中国人民解放军第二军医大学药学院任职讲师；2017.1-2019.2在中国人民解放军海军军医大学开展博士后研究；2019年入职太阳成集团tyc7111cc。长期围绕心血管系统疾病开展相关基础研究与新药成果转化，主要方向：1）、活性天然产物的靶标发现、结构优化与成药性研究；2）、心脑血管系统疾病的药物安全高效递送技术；3）、心脑血管创制新药的研究与开发。参与中药Ⅰ类新药的临床前研究及临床研究；申请国家发明专利3项，其中一项已转让与药企。主持或参与国家自然科学基金、上海市自然科学基金面上项目、科技部高端外专项目、上海市卫计委临床研究专项、上海市科委生物医药科技支撑专项、国家重大新药创制计划、太阳成集团tyc7111cc青年英才启航计划（2022）、药企委托开发横向课题等10项。在包括ACS nano、Advanced science、Journal of Controlled release等权威期刊上发表科研论文30余篇。
主要研究领域
1. 活性天然产物的靶标发现、结构优化与成药性研究：采用定量化学蛋白质组技术探讨活性天然产物的靶蛋白与结合模式，阐明作用机制。针对靶标蛋白质的功能结构，利用优势骨架和功能导向合成策略开展结构优化、合成和成药性研究；
2. 心脑血管系统疾病的药物安全高效递送技术；
3. 心脑血管创制新药的研究与开发：中药Ⅰ类新药“XXX”的临床前研究及Ⅰ期临床研究；心血管类创制新药的临床前研究与开发。
代表性学术成果
论文
1. Wei Su#, Heming Chen#, Yi Li#, Yun Wang, Ting Chen, Hao Shi, Jian Yang, Chuan Zhang*, Tingfang Wang*, Liyan Xiong*. Design, synthesis and biological evaluation of 2-arylbenzo[b]furan-4-vinylcarbonyl derivatives based on Salvianolic acid C as antioxidant neuroprotective agents for the treatment of ischemic stroke. European Journal of Medicinal Chemistry, 2025, 290: 117506.
2. Heming Chen#, Wei Su#, Tingting Li, Yun Wang, Zhuangyu Li, Liyan Xiong, Zhe-Sheng Chen*, Chuan Zhang*, Tingfang Wang*. Recent advances in small molecule design strategies against hepatic fibrosis. European Journal of Medicinal Chemistry, 2025, 286: 117281.
3. Jinhui Fan#, Zhicheng Xiao#, Yafen Dong#, Fei Ye, Yan Qiu, Chuan Zhang*, Xiaolan Yin*, Yi Li*, Tingfang Wang*. Nanocarrier-Mediated RNA Delivery Platform as a Frontier Strategy for Hepatic Disease Treatment: Challenges and Opportunities. Adv Healthcare Mater. 2025, 14(4): e2402933.
4. Zhicheng Xiao#, Yi Li#, Ting Chen#, Chenchen Xie, Jun Liao, Pu Lin, Zhe-Sheng Chen, Yan Qiu*, Jian Cai*, Chuan Zhang*, Tingfang Wang*. A novel nitric oxide-driven nanomotor for synergistic treatment of ischaemic stroke: Enhanced deep brain penetration and therapeutic efficacy. Chemical Engineering Journal. 2024, 496: 154205.
5. Jun Liao#, Yi Li#, Li Fan#, Yuhan Sun#, Zhengyan Gu, Qing-Qiang Xu, Yun Wang, Liyan Xiong, Kai Xiao, Zhe-Sheng Chen, Zhiwei Ma*, Chuan Zhang*, Tingfang Wang*, Ying Lu*. Bioactive Ceria Nanoenzymes Target Mitochondria in Reperfusion Injury to Treat Ischemic Stroke. ACS Nano, 2024, 18(7): 5510-5529. （封面文章）
6. Yi Li, Jun Liao, Liyan Xiong, Zhicheng Xiao, Fei Ye, Yun Wang, Ting Chen, Linzhang Huang, Min Chen, Zhe-Sheng Chen*, Tingfang Wang*, Chuan Zhang*, Ying Lu*. Stepwise targeted strategies for improving neurological function by inhibiting oxidative stress levels and inflammation following ischemic stroke. Journal of Controlled Release. 2024, 368, 607-622.
7. Chenchen Xie#, Jun Liao#, Ning Zhang#, Yuhan Sun, Yi Li, Liyan Xiong, Yingnan Zhang, Xiaoyan Liu, Wei Su, Heming Chen, Ping Zeng, Xiaoqing Zhang∗, Ying Lu∗, Tingfang Wang∗, Chuan Zhang∗. Advanced nano drug delivery systems for neuroprotection against ischemic stroke. Chinese Chemical Letters. 2024, 35(2): 109149.
8. Jun Liao#, Li Fan#, Yi Li#, Qing-Qiang Xu, Li-Yan Xiong, Shan-Shan Zhang, Ji-Hao Liu, Zhi-Cheng Xiao, Chuan Zhang, Jian Yang, Zhe-Sheng Chen*, Kai Xiao*, Ting-Fang Wang*, Ying Lu*. Recent advances in biomimetic nanodelivery systems: New brain-targeting strategies. Journal of Controlled Release. 2023, 358, 439-464.
9. Zhicheng Xiao#, Yi Li#, Liyan Xiong#, Jun Liao, Yijun Gao, Yunchun Luo, Yun Wang, Ting Chen, Dahai Yu*, Tingfang Wang*, Chuan Zhang*, Zhe-Sheng Chen*. Recent Advances in Anti-Atherosclerosis and Potential Therapeutic Targets for Nanomaterial-Derived Drug Formulations. Advanced science, 2023, 10(29): 2302918.
10. Yi Li#, Yunchun Luo#, Jing Wang#, Hao Shi, Jun Liao, Yan Wang Zhesheng Chen, Liyan Xiong*, Chuan Zhang*, TingfangWang*. Discovery of novel danshensu derivatives bearing pyrazolone moiety as potential anti-ischemic stroke agents with antioxidant activity. Bioorganic Chemistry. 131 (2023) 106283.
11. Jun Liao#, Yi Li#, Yunchun Luo, Sha Meng, Chuan Zhang, Liyan Xiong*, Tingfang Wang*, and Ying Lu*. Recent Advances in Targeted Nanotherapies for Ischemic Stroke. Molecular. Pharmaceutics. 2022, 19, 3026-3041.
参编著作
1. 《中国药用植物志》第九卷，北京大学出版社，2017年，参编；
2. 《智能医学概论》中国铁道出版社，2018年，参编。
